A repository of RNA structure probing by chemical or enzymatic mapping

The RNA Mapping Database is an archive that contains results of diverse structural mapping experiments performed on ribonucleic acids. Results submitted to the repository must be manually curated and annotated, ensuring that the data reported is reliable and of high quality. The ultimate goal of the RMDB is to provide a centralized, curated, data-sharing platform with visualization and structure prediction tools for rapid analysis and meta-analysis of these data.

In the RMDB you can:

The RMDB is currently housing 177 entries, for more than 79019 sequences, comprising 8267371 datapoints.

Standardizing chemical footprinting data

This site provides tools and format specifications to make sharing of these experimental data easier and faster.

Want to register?

Register to the site to submit your data to the database and more!

Play the game!

RNA structure can be fun as well. Join the EteRNA community in the quest for the perfect structure. Your contribution may end up in this database!

Database integration

Please contact us if your lab would like to share RNA structure mapping data through this database.

Citation

P Cordero, JB Lucks, R Das, "An RNA Mapping Database for curating RNA structure mapping experiments", 2012, doi: 10.1093/bioinformatics/bts554


RMDB news

  • July 13, 2014:We have acquired two-dimensional MOHCA-seq proximity mapping data for the twelfth RNA puzzle. Analyzed proximity data are available as entries RNAPZ12_MCA_0000 and RNAPZ12_MCA_0001, and raw sequencing data are available as entries RNAPZ12_MCA_0002 and RNAPZ12_MCA_0003.
  • July 9, 2014:We have acquired one-dimensional SHAPE, DMS, and CMCT data for the twelfth RNA puzzle. Data are available as entries RNAPZ12_1M7_0000, RNAPZ12_DMS_0000, and RNAPZ12_CMC_0000.
  • July 7, 2014:We have acquired two-dimensional mutate-and-map data (SHAPE and DMS) for the twelfth RNA puzzle. Data are available as entries RNAPZ12_1M7_0003, and RNAPZ12_DMS_0003.
  • Nov. 19, 2013:We have acquired one-dimensional SHAPE, DMS, and CMCT measurements, two-dimensional mutate-and-map data (1M7, NMIA and DMS), as well as new mutation/rescue for the 16S rRNA Four-Way Junction. Data is available as entries 16SFWJ_STD_0001, 16SFWJ_1M7_0001, 16SFWJ_NMIA_0001, 16SFWJ_DMS_0001, and 16SFWJ_RSQ_0001.
  • July 3, 2013:Welcome to Eterna players who want to look at raw data for the Eterna cloud lab! New entries are available for many of the data sets from early 2013, including Cloud Labs 1, 2, 3, and 4, as well as the pilot player projects from 2012, here and here.
  • May 23, 2013:We have gathered DMS, CMCT, and 1M7 standard-state data for RNA Puzzles 10. RNA Puzzle 10 features two RNAs in complex with one another. Data were gathered for both RNAs in complex and in isolation. The data for RNA #1 is available at RNAPZ10_STD_0001, and the data for RNA #2 is available at RNAPZ10_STD_0002.
  • May 23, 2013:We have acquired one-dimensional SHAPE, DMS, and CMCT measurements for the ninth RNA puzzle, under a series of analogue ligand conditions. Data is available as entries RNAPZ9_ALG_0001.
  • May 15, 2013:We have acquired two-dimensional mutate-and-map data (CMCT and nomod) for the eighth RNA Puzzle. Data are available as entries RNAPZ8_CMCT_0001, and RNAPZ8_nomod_0001. We have also acquired one-dimensional HRF (hydroxyl radical footprinting) measurements for the eighth RNA Puzzle. Data is available as entry RNAPZ8_HRF_0001,
  • May 14, 2013:Data from the EteRNA cloud lab is here! In one shot, we now have expanded our database by more than 5-fold to 4 million data points. And this pipeline will continue, with additional experimental cycles once a month (or more frequently). Check out the EteRNA entries when you browse. And check out EteRNA to join this project in cloud biochemistry!
  • May 10, 2013:We have acquired two-dimensional mutate-and-map data (CMCT and nomod) for the ninth RNA Puzzle. Data are available as entries RNAPZ9_CMCT_0001, and RNAPZ9_nomod_0001.

Download all RMDB entries: You can download all entries indexed in the RMDB here